Folate Deficiency: Neural Tube Defects, Anaemia, and Fortification Policy in Africa
In Sub-Saharan Africa, the estimated prevalence of neural tube defects (NTDs) ranges from 1 to 10 per 1,000 live births across different regions - figures that are broadly two to five times higher than those observed in countries where mandatory folic acid fortification of staple foods has been in place for over two decades.1 In the United States, mandatory fortification of wheat flour introduced in 1998 was followed by a 26–36% reduction in NTD-affected pregnancies; in Canada, the corresponding decline exceeded 40%.2 The contrast is sharp. Across most of SSA, fortification programmes either do not exist, are voluntary rather than mandatory, or achieve coverage too partial to generate population-level reductions in NTD prevalence. The result is a largely preventable burden of spina bifida, anencephaly, and encephalocele that falls disproportionately on women with the least access to periconceptional supplementation.